Hot Topics at AHA Meeting 2025

 Here is a list of all the hot topics at AHA 2025 based on the latest information:

• 27 late-breaking science (LBS) presentations over seven sessions

• First-in-human CRISPR-Cas9 gene-editing therapy targeting ANGPTL3 (lipid metabolism)

• POLY-HF trial testing polypill strategy in heart failure patients

• OCEAN trial on optimal antithrombotic strategy post-AF ablation (rivaroxaban vs aspirin)

• META-AF trial examining metformin after AF ablation

• DARE-AF trial on SGLT2 inhibitors post-AF ablation

• DECAF trial testing whether quitting coffee reduces recurrent AF risk

• RECOVERY trial comparing early surgery vs conservative management in asymptomatic severe aortic stenosis

• FAVOR IV-QVAS trial investigating FFR-guided CABG outcomes in valve surgery patients with CAD

• CORALreef Lipids study of oral PCSK9 inhibitor enlicitide decanoate

• SSTT study on oral potassium chloride supplementation for blood pressure control in hypertension

• BETTER-BP, GoFresh, and Healthy Family Program trials on dietary and lifestyle interventions for blood pressure reduction

• CELEBRATE trial on zalunfiban pretreatment in STEMI patients undergoing PCI

• CorCMR trial on noninvasive endotyping in angina without obstructive coronary disease

• CAVIAR trial assessing PCSK9 inhibitor for cardiac allograft vasculopathy inhibition

• SURPASS-CVOT trial comparing tirzepatide vs dulaglutide on heart failure outcomes in type 2 diabetes with cardiovascular disease

• Five late-breaking basic science sessions covering genetics, coagulation, lipid research, bioartificial organs, pregnancy-related hypertensive disorders, and artificial intelligence

• Short, punchy "TED talk"-style special sessions focusing on key takeaways from complex science accessible to general cardiology audience

• Hypertrophic Cardiomyopathy Medical Society program running all day Saturday

• Plenary sessions hosted by TCT including intravascular imaging, hemodynamic support, coronary physiology, renal denervation

• Resuscitation Science Symposium running November 8 and 9

• Nobel Laureate Ardem Patapoutian lecture on mechanical sensing receptors

• Paul Dudley White lecture by Susan R. Davis on sex hormones in cardiometabolic health

These topics highlight a broad and cutting-edge agenda addressing clinical trials, basic science, technology innovations, and practical cardiology discussions at AHA 2025.